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Hormone levels can predict premature death in kidney patients

Posted On: Sept. 10, 2011

Washington, Sept 10 (ANI): High levels of a specific hormone can predict which kidney patients will develop heart problems, require dialysis or die prematurely, according to researchers at the University of Colorado School of Medicine.

"This discovery allows us to predict at-risk patients before they require dialysis," said lead investigator Michel Chonchol, MD, an associate professor of medicine specializing in nephrology.

Chonchol and fellow CU School of Medicine researcher Jessica Kendrick, MD, studied the blood plasma of patients with advanced kidney disease and found that levels of fibroblast growth factor-23, a hormone known as FGF-23, increased as the patient's kidney function decreased.

The hormone regulates phosphorous levels in the body. As the kidneys fail, they are unable to excrete phosphorous which raises FGF-23 levels. The higher the hormone levels, the greater chance the patient will die.

By the time a patient is down to just 30 or 40 percent kidney function, the levels of FGF-23 can predict who will die, have a cardiac event or end up on dialysis.

Until now, doctors relied on measuring phosphorous to assess phosphate balance in patients with kidney disease.

But Chonchol found that long before phosphorous levels jump, FGF-23 levels have already increased.

Identifying this earlier will allow doctors to intervene with drugs that can lower phosphorous which would then lower the hormone level.

"This has provided us a critical marker to look for. A marker that could save lives," Chonchol stated.

The findings were published Friday in the Journal of the American Society of Nephrology. (ANI)

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